![]() With the development of assisted reproductive technology (ART), many patients have benefited greatly from frozen embryo transfer (FET) to achieve pregnancy. Because this was a retrospective study design, selection bias is possible, although the baseline characteristics of the 2 groups of patients were matched. ![]() NC is as effective as HRC after 2 previous cycles of HRC. It is concluded by binary regression analysis that the different endometrial preparation protocol have no significant effect on the CPR. There were no significant differences in the rates of biochemical pregnancy, clinical pregnancy, cumulative pregnancy, miscarriage, multiple pregnancy, ectopic pregnancy, or live birth between the 2 groups. We found that on the day of endometrial transformation, estrogen levels and endometrial thickness in the NC group were significantly higher than those in the HRC group. Confounding factors that may affect clinical pregnancy rates were analyzed. The pregnancy outcomes for the 2 groups were compared. Patients were divided into groups based on the method of endometrial preparation: 98 were classified as NC and 76 as HRC. All the embryos were obtained during the same oocyte retrieval cycle. They had undergone 2 consecutive failed cycles of endometrial preparation with hormone replacement therapy and prepare for the third frozen embryo transplantation.Ī third cycle of treatment was planned using either NC or HRC for endometrial preparation. The 174 patients were all infertile with regular menstruation. Retrospective study of 174 patients in the reproductive medicine center of an affiliated hospital of Shandong University of Traditional Chinese Medicine between January 2015 and September 2018. įor frozen embryo transplantation patients who failed to use hormone replacement cycle (HRC) transplantation for 2 consecutive times, the third time of transplantation was divided into 2 groups: HRC and natural cycle (NC), and the pregnancy rate of the 2 groups, especially the clinical pregnancy rate, was compared. The work cannot be used commercially without permission from the journal. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request. The authors have no conflicts of interest to disclose. This work was supported by the National Natural Science Foundation of China under Grant. A comparison of pregnancy rate between natural cycle and hormone replacement cycle in patients who underwent frozen embryo transfer using 2 consecutive hormone replacement regiments: A STROBE-compliant retrospective study. How to cite this article: Pang C, Guo L, Bi Y, Wang K, Lian F, Wu Z, Xu X, Sun Z. ∗Correspondence: Zhengao Sun, The Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, China (e-mail: ).Ībbreviations: ART = assisted reproductive technology, FET = frozen embryo transfer, hCG = human chorionic gonadotrophin, HRC = hormone replacement cycle, ICSI = intracytoplasmic sperm injection, IVF = in vitro fertilization, NC = natural cycle. ![]() ACenter for Reproduction and Genetics Integrated Traditional Chinese and Western Medicine, The Hospital Affiliated of Shandong University of Traditional Chinese MedicineīThe Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
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